With four teams on bye and two games already in the books, a lighter schedule than usual for Week 6 Sunday – the two big games of the day: Chargers at Ravens at 1 and Cardinals at Browns at 4. Lots of road dogs, so lots of uncertainty in today’s card.
| Time | Date | Away | Home | Line | Predictor |
| 1:00 | 17-Oct | Minnesota | Carolina | 2 | Carolina |
| 1:00 | 17-Oct | LA Chargers | Baltimore | -3 | Baltimore +1 |
| 1:00 | 17-Oct | LA Rams | NY Giants | 7.5 | LA Rams +1 |
| 1:00 | 17-Oct | Houston | Indianapolis | -10.5 | Indianapolis +1 |
| 1:00 | 17-Oct | Kansas City | Washington | 6.5 | Kansas City |
| 1:00 | 17-Oct | Green Bay | Chicago | 5.5 | Green Bay |
| 1:00 | 17-Oct | Cincinnati | Detroit | 3.5 | Detroit |
| 4:05 | 17-Oct | Arizona | Cleveland | -3 | Cleveland |
| 4:25 | 17-Oct | Dallas | New England | 3.5 | New England |
| 4:25 | 17-Oct | Las Vegas | Denver | -5 | Denver |
| 8:20 | 17-Oct | Seattle | Pittsburgh | -5 | Seattle |
| 8:20 | 18-Oct | Buffalo | Tennessee | 6 | Tennessee |